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24 changes: 24 additions & 0 deletions datasets/salk-aging-mouse-brain-epigeneti.yaml
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Name: Aging Mouse Brain Epigeneti
Description: "Aging is a major risk factor for neurodegenerative diseases, yet underlying epigenetic mechanisms remain unclear. Here, we generated a comprehensive single-nucleus cell atlas of brain aging across multiple brain regions, comprising 132,551 single-cell methylomes and 72,666 joint chromatin conformation-methylome nuclei. Integration with companion transcriptomic and chromatin accessibility data yielded a cross-modality taxonomy of 36 major cell types."
Contact: [email protected]
Documentation: https://doi.org/10.1101/2025.04.21.648266
ManagedBy: "[Salk Institute](http://www.salk.edu)"
UpdateFrequency: Never
Tags:
- life sciences
- genetic
- genomic
- whole genome sequencing
- whole exome sequencing
- transcriptomics
- fastq
- bam
- cram
- STRIDES
License: "[NCBI Policy](https://www.ncbi.nlm.nih.gov/home/about/policies/) and [NIH Genomic Data Sharing Policy ](https://osp.od.nih.gov/scientific-sharing/genomic-data-sharing/)"
DataAtWork:
Publications:
- Title: Cell-type-specific transposable element demethylation and TAD remodeling in the aging mouse brain
URL: https://doi.org/10.1101/2025.04.21.648266
AuthorName: Zeng, Q., Wei, T., Klein, A., Bartlett, A., Liu, H., Nery, J.R., Castanon, R., Osteen, J., Johnson, N.D., Wang, W., Ding, W., Chen, H., Altshul, J., Kenworthy, M., Valadon, C., Owens, W., Wu, Z., Amaral, M.L., Song, Báez-Becerra, T.a.t.i.a.n.a., Cho, S., Chen, C., Willier, J., Cao, S., Rink, J., Lee, J., Barcoma, A., Arzavala, J., Emerson, N., Lu, Y.R., Ren, B., Behrens, M.a.r.g.a.r.i.t.a., Ecker, J.R.
AuthorURL: https://www.salk.edu/scientist/joseph-ecker/