diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 54b6d6a7ea..4a43c39721 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -81,6 +81,18 @@ jobs:
             v8_enable_pointer_compression: true
             cargo: cargo
 
+          - os: ${{ github.repository == 'denoland/rusty_v8' && 'ubuntu-22.04-xl' || 'ubuntu-22.04' }}
+            target: x86_64-unknown-linux-musl
+            variant: debug
+            v8_enable_pointer_compression: false
+            cargo: cargo
+
+          - os: ${{ github.repository == 'denoland/rusty_v8' && 'ubuntu-22.04-xl' || 'ubuntu-22.04' }}
+            target: x86_64-unknown-linux-musl
+            variant: release
+            v8_enable_pointer_compression: false
+            cargo: cargo
+
           - os: ${{ github.repository == 'denoland/rusty_v8' && 'windows-2022-xxl' || 'windows-2022' }}
             target: x86_64-pc-windows-msvc
             variant: release # Note: we do not support windows debug builds.
@@ -183,6 +195,8 @@ jobs:
                "aarch64-apple-darwin"      = "aarch64-apple-darwin"
                "x86_64-unknown-linux-gnu"  = "x86_64-unknown-linux-musl"
                "aarch64-unknown-linux-gnu" = "aarch64-unknown-linux-musl"
+               "x86_64-unknown-linux-musl"  = "x86_64-unknown-linux-musl"
+               "aarch64-unknown-linux-musl" = "aarch64-unknown-linux-musl"
                "x86_64-pc-windows-msvc"    = "x86_64-pc-windows-msvc"
              }['${{ matrix.config.target }}']
           $basename = "sccache-$version-$platform"
@@ -217,7 +231,7 @@ jobs:
       - name: Test (ASAN)
         env:
           SCCACHE_IDLE_TIMEOUT: 0
-        if: matrix.config.variant == 'asan'
+        if: matrix.config.variant == 'asan' && matrix.config.target != 'x86_64-unknown-linux-musl'
         # https://github.com/rust-lang/rust/issues/87215
         run: |
           rustup component add rust-src --toolchain nightly-${{ matrix.config.target }}
@@ -226,10 +240,19 @@ jobs:
           tar -C tools/clang/dsymutil/ -xvzf dsymutil-llvmorg-17-init-19076-g5533fc10-1.tgz
           V8_FROM_SOURCE=true RUSTFLAGS="-C opt-level=1 -Zsanitizer=address" cargo +nightly -Z build-std nextest run --lib --bins --tests -v --cargo-verbose --cargo-verbose --target ${{ matrix.config.target }}
 
+      - name: Test (Musl)
+        env:
+          SCCACHE_IDLE_TIMEOUT: 0
+        if: matrix.config.target == 'x86_64-unknown-linux-musl'
+        run: |
+          docker run -v "$PWD":/usr/src/rusty_v8 -w /usr/src/rusty_v8 rust:alpine3.21 ./musl-build.sh ${{ env.CARGO_VARIANT_FLAG }}
+          docker cp $(docker ps -lq):/usr/src/rusty_v8/target/${{ matrix.config.variant }}/gn_out/obj/librusty_v8.a target/librusty_v8_${{ matrix.config.variant }}_x86_64-unknown-linux-musl.a
+          sudo chown -R $(id -u):$(id -g) /home/runner/work/rusty_v8/rusty_v8/target/
+
       - name: Test
         env:
           SCCACHE_IDLE_TIMEOUT: 0
-        if: matrix.config.variant == 'debug' || matrix.config.variant == 'release'
+        if: (matrix.config.variant == 'debug' || matrix.config.variant == 'release') && matrix.config.target != 'x86_64-unknown-linux-musl'
         run: ${{ matrix.config.cargo }} nextest run -v --cargo-verbose --cargo-verbose --all-targets --locked --target ${{ matrix.config.target }} ${{ env.CARGO_VARIANT_FLAG }} ${{ env.CARGO_FEATURE_FLAGS }}
 
       - name: Clippy
diff --git a/musl-build.sh b/musl-build.sh
new file mode 100755
index 0000000000..490d25fb19
--- /dev/null
+++ b/musl-build.sh
@@ -0,0 +1,29 @@
+#!/bin/sh
+
+apk add git \
+    gcc \
+    ninja \
+    python3 \
+    g++ \
+    pkgconfig \
+    glib-dev \
+    binutils-gold
+ln -s /usr/bin/python3 /usr/bin/python
+
+export V8_FROM_SOURCE="yes"
+export GN_ARGS="use_custom_libcxx=false use_lld=false v8_enable_backtrace=false v8_enable_debugging_features=false"
+GN="$(pwd)/gn/out/gn"
+export GN
+
+# Build GN
+if [ ! -d "./gn" ]; then
+    git clone https://gn.googlesource.com/gn
+    (
+        cd gn || exit
+        python3 build/gen.py
+        ninja -C out
+    )
+fi
+
+# Build rusty_v8 and pass through the arguments
+cargo build -vv $@ --target=x86_64-unknown-linux-musl