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30x whole genome and $0.21 for whole exome (not considering preemption).
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***Speed** - See [metrics](docs/metrics.md) for the runtime of all supported
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datatypes on a 64-core CPU-only machine</sup>. Multiple options for
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acceleration exist, taking the WGS pipeline to as fast as 40 minutes
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(see [external solutions](#external-solutions)).
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acceleration exist.
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***Usage options** - DeepVariant can be run via Docker or binaries, using
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both on-premise hardware or in the cloud, with support for hardware
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accelerators like GPUs and TPUs.
@@ -183,21 +181,6 @@ Name
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[Build from source](docs/deepvariant-build-test.md) | DeepVariant comes with scripts to build it on Ubuntu 20.04. To build and run on other Unix-based systems, you will need to modify these scripts.
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Prebuilt Binaries | Available at [`gs://deepvariant/`](https://console.cloud.google.com/storage/browser/deepvariant). These are compiled to use SSE4 and AVX instructions, so you will need a CPU (such as Intel Sandy Bridge) that supports them. You can check the `/proc/cpuinfo` file on your computer, which lists these features under "flags".
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### External Solutions
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The following pipelines are not created or maintained by the
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[Genomics team in Google Health](https://health.google/health-research/).
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Please contact the relevant teams if you have any questions or concerns.
[Running DeepVariant on Google Cloud Platform](https://cloud.google.com/genomics/docs/tutorials/deepvariant) | Docker-based pipelines optimized for cost and speed. Code can be found [here](https://github.com/googlegenomics/gcp-deepvariant-runner).
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[DeepVariant-on-spark from ATGENOMIX](https://github.com/atgenomix/deepvariant-on-spark) | A germline short variant calling pipeline that runs DeepVariant on Apache Spark at scale with support for multi-GPU clusters (e.g. NVIDIA DGX-1).
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[NVIDIA Clara Parabricks](https://www.nvidia.com/en-us/docs/parabricks/variant-callers/deepvariant/) | An accelerated DeepVariant pipeline with multi-GPU support that runs our WGS pipeline in just 40 minutes, at a cost of $2-$3 per sample. This provides a 7.5x speedup over a 64-core CPU-only machine at lower cost.
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[DNAnexus DeepVariant App](https://platform.dnanexus.com/app/deepvariant_germline) | Offers parallelized execution with a GUI interface (requires platform account).
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[Nextflow Pipeline](https://github.com/nf-core/deepvariant) | Offers parallel processing of multiple BAMs and Docker support.
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