diff --git a/testing/cffi0/test_zintegration.py b/testing/cffi0/test_zintegration.py
index 8d71d81b..3daf4a5c 100644
--- a/testing/cffi0/test_zintegration.py
+++ b/testing/cffi0/test_zintegration.py
@@ -17,14 +17,14 @@ def create_venv(name):
     try:
         # FUTURE: we should probably update this to use venv for at least more modern Pythons, and
         # install setuptools/pip/etc explicitly for the tests that require them (as venv has stopped including
-        # setuptools and wheel by default for newer versions).
+        # setuptools by default for newer versions).
         subprocess.check_call(['virtualenv', 
             #'--never-download', <= could be added, but causes failures
             # in random cases on random machines
                                '-p', os.path.abspath(sys.executable),
                                str(tmpdir)])
 
-        # Newer venv/virtualenv no longer include setuptools and wheel by default, which
+        # Newer venv/virtualenv no longer include setuptools by default, which
         # breaks a number of these tests; ensure they're always present
         subprocess.check_call([
             os.path.join(tmpdir, 'bin/python'),
@@ -32,7 +32,6 @@ def create_venv(name):
             'pip',
             'install',
             'setuptools',
-            'wheel',
             '--upgrade'
         ])
 
@@ -98,7 +97,7 @@ def remove(dir):
         # there's a setuptools/easy_install bug that causes this to fail when the build/install occur together and
         # we're in the same directory with the build (it tries to look up dependencies for itself on PyPI);
         # subsequent runs will succeed because this test doesn't properly clean up the build- use pip for now.
-        subprocess.check_call((vp, '-m', 'pip', 'install', '.'), env=env)
+        subprocess.check_call((vp, '-m', 'pip', 'install', '.', '--no-build-isolation'), env=env)
         subprocess.check_call((vp, str(python_f)), env=env)
     finally:
         os.chdir(olddir)