diff --git a/misc/benchmark_mode.rb b/misc/benchmark_mode.rb
new file mode 100644
index 00000000..26ab75dd
--- /dev/null
+++ b/misc/benchmark_mode.rb
@@ -0,0 +1,368 @@
+# frozen_string_literal: true
+
+require "etc"
+require "open3"
+
+module BenchmarkMode
+  BENCH_SET = "bench"
+  OTHER_SET = "other"
+
+  module Helpers
+    extend self
+
+    # Transform a list like "0,2-4,7" into an array of integers.
+    def list_to_ints(list)
+      list
+        &.split(',')
+        &.flat_map { |s| a, b = s.split('-').map(&:to_i); b ? a.upto(b).to_a : [a] }
+    end
+  end
+
+  class << self
+    # Enable all available settings.
+    def engage!(nice: nil)
+      # Set scheduler priority ("niceness") for this process (and any child processes).
+      Nice.renice_process_group!(nice || -15, Process.getpgrp)
+
+      return unless bench_cpus = find_bench_cpus
+
+      # Create "bench" cpuset for our task (and forks).
+      bench_tasks = [$$]
+      CpuSet.new(BENCH_SET, cpus: bench_cpus, tasks: bench_tasks, sched_load_balance: '0').create
+
+      # Put all other tasks in "other" cpuset.
+      other_tasks = all_tasks - bench_tasks
+      other_cpus = all_cpus - bench_cpus
+      CpuSet.new(OTHER_SET, cpus: other_cpus, tasks: other_tasks).create
+
+      # Disable the hyper thread siblings of our CPUs
+      # so that nothing gets put on the physical core we are using.
+      @hyper_thread_siblings = []
+      bench_cpus.each do |cpu|
+        @hyper_thread_siblings.concat(HyperThreading.new(cpu:).disable)
+      end
+
+      # Pin current task (coordinator) to first CPU
+      # so the benchmarks can run alone on the second.
+      CpuAffinity.pin!(bench_cpus.first, $$)
+
+      bench_cpus.last
+    end
+    alias enable! engage!
+
+    # Restore settings to their defaults.
+    def disengage!
+      [OTHER_SET, BENCH_SET].each do |set|
+        CpuSet.new(set).destroy
+      end
+
+      # If we know which ones we took offline, restore those.
+      if @hyper_thread_siblings&.any?
+        @hyper_thread_siblings.each do |sib|
+          CPU.enable(sib)
+        end
+      else
+        # Otherwise just re-enable all CPUs.
+        Sudo.write(Dir.glob("#{CPU::ROOT}/cpu*/online"), 1)
+      end
+
+      # Don't return the above value.
+      nil
+    end
+    alias disable! disengage!
+
+    # Get thread id's of all running processes.
+    def all_tasks
+      # In cgroup v2 the task list doesn't necessarily include all thread id's.
+      (CpuSet.tasks + "\n" + `ps -eo tid=`).lines.map(&:strip).map(&:to_i).uniq
+    end
+
+    # Get list of all cpu numbers.
+    def all_cpus
+      return @all_cpus if defined?(@all_cpus)
+
+      # Read from root cpuset so our view is not limited by any current cpuset.
+      @all_cpus = Helpers.list_to_ints(CpuSet.cpus)
+
+      # If that didn't work just guess at it.
+      @all_cpus ||= (0 ... Etc.nprocessors).to_a
+    end
+
+    # Determine which cpu numbers to use for benchmarking.
+    # TODO: look at cpus in use, grab the ones with the least amount of (kernel) tasks?
+    def find_bench_cpus
+      # If we have enough CPUs, just pick some:
+      # one for the coordinator
+      # one for the actual benchmarks
+      [1, 2] if all_cpus.size > 4
+    end
+  end
+
+  # Wrapper functions to enable commands to be run as root
+  # without requiring the whole benchmark suite to have been started by root.
+  module Sudo
+    extend self
+
+    def log(msg)
+      STDERR.puts msg
+    end
+
+    # Run command with escalated privileges.
+    def sudo(*command, **kwargs)
+      log "$ sudo #{command.join(" ")}"
+      system("sudo", *command, **kwargs)
+    end
+
+    # Write file with escalated privileges.
+    def write(path, content, verbose: true)
+      content = content.to_s
+
+      # Limit to X items at a time to avoid command line argument limits.
+      Array(path).select { |p| File.exist?(p) }.each_slice(50) do |paths|
+        cmd = ["sudo", "tee", *paths]
+        if verbose
+          log "$ echo #{content} | sudo #{cmd.join(" ")}"
+        end
+
+        Open3.popen3(*cmd) do |stdin, stdout, stderr, thread|
+          stdin.write(content)
+          stdin.close
+
+          err = stderr.read.strip
+          if !err.empty? && err !~ /No such process|Invalid argument/
+            if !verbose
+              log "$ echo #{content} | sudo #{cmd.join(" ")}"
+            end
+            puts err
+          end
+        end
+      end
+    end
+  end
+
+  # Manage whether CPUs are on or offline.
+  class CPU
+    ROOT = "/sys/devices/system/cpu"
+
+    class << self
+      include Sudo
+
+      def enable(n)
+        set(n, :online, 1)
+      end
+
+      def disable(n)
+        set(n, :online, 0)
+      end
+
+      def set(n, key, val)
+        write("#{ROOT}/cpu#{n}/#{key}", val)
+      end
+    end
+  end
+
+  # Manage cpu hyper-threading.
+  # If we want to pin our benchmarks to a single cpu,
+  # we disable the hyper-threading sibling cpu
+  # so that another process can't use (even the thread sibling of) that cpu.
+  class HyperThreading
+    attr_reader :cpu
+
+    def initialize(cpu:)
+      @cpu = cpu
+    end
+
+    def list_path
+      "#{CPU::ROOT}/cpu#{cpu}/topology/thread_siblings_list"
+    end
+
+    # Take sibling CPUs offline and return the list of modified CPUs.
+    def disable
+      altered = []
+
+      if File.exist?(list_path)
+        siblings = Helpers.list_to_ints(File.read(list_path))
+        siblings.each do |sib|
+          next if sib == cpu
+
+          altered << sib
+          CPU.disable(sib)
+        end
+      end
+
+      altered
+    end
+  end
+
+  # Manage (cgroup) cpusets to limit tasks to specified cpus.
+  class CpuSet
+    include Sudo
+
+    # If cgroup v2 is mounted (systemd unified hierarchy) but not managing
+    # cpusets we can mount them and use them in the old fashion.
+    # If cgroup v2 is managing cpusets we can integrate with the already mounted fs.
+    # If cpusets aren't being managed by v2 you can enable it with:
+    # echo +cpuset | sudo tee /sys/fs/cgroup/cgroup.subtree_control
+    # (provided you don't have a cpusets mount somewhere else).
+
+    CGROUP_V2_ROOT = "/sys/fs/cgroup"
+
+    # Man cpuset(7) says "/dev/cpuset" but mounting there may fail when /dev is a devtmpfs.
+    DEFAULT_ROOT = "/cpusets"
+
+    def self.find_root
+      return @root if defined?(@root)
+
+      unless File.read("/proc/filesystems").lines.detect { |line| line =~ /^nodev\s+cpuset$/ }
+        return @root = nil
+      end
+
+      # If it's already mounted use the current path.
+      File.read("/proc/mounts").lines.each do |line|
+        if %r{^\S+ (?<mountpoint>/\S+) cgroup (?:[^ ]*,)?cpuset[, ]} =~ line
+          return @root = mountpoint
+        end
+      end
+
+      if read("cgroup.subtree_control", CGROUP_V2_ROOT)&.split(' ')&.include?('cpuset')
+        @cgroup_v2 = true
+        return @root = CGROUP_V2_ROOT
+      end
+
+      @root = DEFAULT_ROOT.then do |dir|
+        Sudo.sudo("mkdir", "-p", dir) unless File.exist?(dir)
+
+        Sudo.sudo("mount", "-t", "cpuset", "none", dir)
+
+        # If the fs failed to mount, return nil.
+        dir if File.exist?(self.file_path(:tasks, dir))
+      end
+    end
+
+    V2_PATHS = {
+      cpu_exclusive: "cpuset.cpus.exclusive",
+      cpus: "cpuset.cpus",
+      effective_cpus: "cpuset.cpus.effective",
+      effective_mems: "cpuset.mems.effective",
+      mems: "cpuset.mems",
+      sched_load_balance: nil, # not available in the v2 fs
+      tasks: "cgroup.procs",
+    }
+
+    def self.file_path(name, dir = nil)
+      dir ||= find_root
+      name = V2_PATHS.fetch(name) if cgroup_v2?
+
+      return unless name
+
+      File.join(dir, name.to_s)
+    end
+
+    def self.read(name, dir = nil)
+      path = file_path(name, dir)
+
+      return unless path && File.exist?(path)
+
+      File.read(path)
+    end
+
+    def self.cgroup_v2?
+      @cgroup_v2
+    end
+
+    def self.cpus
+      read(:effective_cpus)&.strip
+    end
+
+    def self.mems
+      read(:effective_mems)&.strip
+    end
+
+    def self.tasks
+      read(:tasks)
+    end
+
+    def initialize(name, cpus: nil, tasks: [], **kwargs)
+      @name = name
+      @cpus = cpus
+      @tasks = tasks
+      @settings = {cpu_exclusive: 1, cpus: Array(cpus).join(",")}.merge(kwargs)
+    end
+
+    # Returns "root/name" if root is defined.
+    def path
+      return @path if defined?(@path)
+
+      @path = self.class.find_root&.then { |root| File.join(root, @name) }
+    end
+
+    # Create directory and write settings to files beneath it.
+    def create
+      return unless path
+
+      unless File.directory?(path)
+        sudo("mkdir", path)
+      end
+
+      # Both cpus and mems must be set in order to add tasks.
+      # Default mems to the root value.
+      @settings[:mems] ||= self.class.mems
+
+      # Settings must be written before tasks can be added.
+      @settings.each_pair do |key, value|
+        write_setting(key, value)
+      end
+
+      # Now we can write the tasks.
+      write_setting(:tasks, @tasks, verbose: false)
+    end
+
+    def write_setting(key, value, verbose: true)
+      key_path = self.class.file_path(key, path)
+      return unless key_path
+
+      # If an array is provided (for "tasks") write each item individually.
+      Array(value).each do |item|
+        write(key_path, item, verbose:)
+      end
+    end
+
+    # Move tasks out of cpuset and remove directory.
+    def destroy
+      return unless path && File.directory?(path)
+
+      # Move tasks to parent cpuset as we cannot remove a set that still has tasks.
+      root_tasks = self.class.file_path(:tasks)
+      File.read(self.class.file_path(:tasks, path)).lines.each do |tid|
+        write(root_tasks, tid, verbose: false)
+      end
+
+      sudo("rmdir", path)
+    end
+  end
+
+  # Modify scheduling priority (niceness).
+  module Nice
+    class << self
+      include Sudo
+
+      # Allow setting a negative priority without
+      # needing this process (or any child) to have been launched by root.
+      def renice_process_group!(priority, group)
+        sudo("renice", priority.to_s, "-g", group.to_s)
+      end
+    end
+  end
+
+  # Set CPU affinity to pin a task to a cpu.
+  module CpuAffinity
+    class << self
+      include Sudo
+
+      def pin!(cpu, pid)
+        # The "p" and "c" options must be grouped together.
+        sudo("taskset", "-pc", cpu.to_s, pid.to_s)
+      end
+    end
+  end
+end
diff --git a/run_benchmarks.rb b/run_benchmarks.rb
index a4eafbdc..af876f97 100755
--- a/run_benchmarks.rb
+++ b/run_benchmarks.rb
@@ -11,6 +11,7 @@
 require 'etc'
 require 'yaml'
 require_relative 'misc/stats'
+require_relative 'misc/benchmark_mode'
 
 # Check which OS we are running
 def os
@@ -58,7 +59,7 @@ def have_yjit?(ruby)
 end
 
 # Disable Turbo Boost while running benchmarks. Maximize the CPU frequency.
-def set_bench_config(turbo:)
+def set_bench_config(turbo:, benchmark_mode:)
   # sudo requires the flag '-S' in order to take input from stdin
   if File.exist?('/sys/devices/system/cpu/intel_pstate') # Intel
     unless intel_no_turbo? || turbo
@@ -74,6 +75,13 @@ def set_bench_config(turbo:)
     end
     check_call("sudo -S cpupower frequency-set -g performance") unless performance_governor?
   end
+
+  if os == :linux && benchmark_mode
+    BenchmarkMode.engage!&.then do |cpu|
+      ENV["YJIT_BENCH_CPU"] = cpu.to_s
+    end
+    at_exit { BenchmarkMode.disengage! }
+  end
 end
 
 def check_pstate(turbo:)
@@ -261,8 +269,10 @@ def run_benchmarks(ruby:, ruby_description:, categories:, name_filters:, out_pat
       # Pin the process to one given core to improve caching and reduce variance on CRuby
       # Other Rubies need to use multiple cores, e.g., for JIT threads
       if ruby_description.start_with?('ruby ') && !no_pinning
-        # The last few cores of Intel CPU may be slow E-Cores, so avoid using the last one.
-        cpu = [(Etc.nprocessors / 2) - 1, 0].max
+        cpu = ENV.fetch("YJIT_BENCH_CPU") do
+          # The last few cores of Intel CPU may be slow E-Cores, so avoid using the last one.
+          [(Etc.nprocessors / 2) - 1, 0].max
+        end
         cmd += ["taskset", "-c", "#{cpu}"]
       end
     end
@@ -320,6 +330,7 @@ def run_benchmarks(ruby:, ruby_description:, categories:, name_filters:, out_pat
   name_filters: [],
   rss: false,
   graph: false,
+  benchmark_mode: true,
   no_pinning: false,
   turbo: false,
 })
@@ -413,6 +424,10 @@ def run_benchmarks(ruby:, ruby_description:, categories:, name_filters:, out_pat
     args.graph = true
   end
 
+  opts.on("--no-benchmark-mode", "Disable cpusets, niceness, hyper-threading toggling") do
+    args.benchmark_mode = false
+  end
+
   opts.on("--no-pinning", "don't pin ruby to a specific CPU core") do
     args.no_pinning = true
   end
@@ -437,8 +452,8 @@ def run_benchmarks(ruby:, ruby_description:, categories:, name_filters:, out_pat
   end
 end
 
-# Disable CPU frequency scaling
-set_bench_config(turbo: args.turbo)
+# Disable CPU frequency scaling, enable cpusets, etc
+set_bench_config(turbo: args.turbo, benchmark_mode: args.benchmark_mode)
 
 # Check pstate status
 check_pstate(turbo: args.turbo)