diff --git a/src/client.rs b/src/client.rs
index 526f0338..dfee5e7e 100644
--- a/src/client.rs
+++ b/src/client.rs
@@ -314,6 +314,28 @@ impl HttpClientBuilder {
         self
     }
 
+    /// Set a mapping of host rule
+    ///
+    /// Entries in the given map will be used first before using the default host
+    /// rules for host+port pairs.
+    ///
+    /// # Examples
+    ///
+    /// ```
+    /// use isahc::{config::HostRuleMap, prelude::*, HttpClient};
+    ///
+    /// let client = HttpClient::builder()
+    ///     .host_rule(HostRuleMap::new()
+    ///         // Send requests for example.org on port 80 to github.com.
+    ///         .add("example.org", 80, "github.com"))
+    ///     .build()?;
+    /// # Ok::<(), Box<dyn std::error::Error>>(())
+    /// ```
+    pub fn host_rule(mut self, map: HostRuleMap) -> Self {
+        self.client_config.host_rule = Some(map);
+        self
+    }
+
     /// Add a default header to be passed with every request.
     ///
     /// If a default header value is already defined for the given key, then a
diff --git a/src/config/client.rs b/src/config/client.rs
index 19fc2b94..fbff4bb5 100644
--- a/src/config/client.rs
+++ b/src/config/client.rs
@@ -1,5 +1,6 @@
 use super::{
     dns::{DnsCache, ResolveMap},
+    host_rule::HostRuleMap,
     request::SetOpt,
 };
 use std::time::Duration;
@@ -10,6 +11,7 @@ pub(crate) struct ClientConfig {
     pub(crate) close_connections: bool,
     pub(crate) dns_cache: Option<DnsCache>,
     pub(crate) dns_resolve: Option<ResolveMap>,
+    pub(crate) host_rule: Option<HostRuleMap>,
 }
 
 impl SetOpt for ClientConfig {
@@ -26,6 +28,10 @@ impl SetOpt for ClientConfig {
             map.set_opt(easy)?;
         }
 
+        if let Some(map) = self.host_rule.as_ref() {
+            map.set_opt(easy)?;
+        }
+
         easy.forbid_reuse(self.close_connections)
     }
 }
diff --git a/src/config/host_rule.rs b/src/config/host_rule.rs
new file mode 100644
index 00000000..68b666ff
--- /dev/null
+++ b/src/config/host_rule.rs
@@ -0,0 +1,39 @@
+//! Configuration of host rule.
+use super::SetOpt;
+
+/// A mapping of host and port pairs to specified host
+///
+/// Entries added to this map can be used to override how host is resolved for a
+/// request and use specific host instead of using the default name
+/// resolver.
+#[derive(Clone, Debug, Default)]
+pub struct HostRuleMap(Vec<String>);
+
+impl HostRuleMap {
+    /// Create a new empty rule map.
+    pub const fn new() -> Self {
+        HostRuleMap(Vec::new())
+    }
+
+    /// Add a host mapping for a given host and port pair.
+    pub fn add<H>(mut self, host: H, port: u16, connect_to_host: H) -> Self
+    where
+        H: AsRef<str>,
+    {
+        self.0
+            .push(format!("{}:{}:{}", host.as_ref(), port, connect_to_host.as_ref()));
+        self
+    }
+}
+
+impl SetOpt for HostRuleMap {
+    fn set_opt<H>(&self, easy: &mut curl::easy::Easy2<H>) -> Result<(), curl::Error> {
+        let mut list = curl::easy::List::new();
+
+        for entry in self.0.iter() {
+            list.append(entry)?;
+        }
+
+        easy.connect_to(list)
+    }
+}
diff --git a/src/config/mod.rs b/src/config/mod.rs
index 50d7a03d..48819ad9 100644
--- a/src/config/mod.rs
+++ b/src/config/mod.rs
@@ -22,12 +22,14 @@ pub(crate) mod client;
 pub(crate) mod dial;
 pub(crate) mod dns;
 pub(crate) mod proxy;
+pub(crate) mod host_rule;
 pub(crate) mod redirect;
 pub(crate) mod request;
 pub(crate) mod ssl;
 
 pub use dial::{Dialer, DialerParseError};
 pub use dns::{DnsCache, ResolveMap};
+pub use host_rule::HostRuleMap;
 pub use redirect::RedirectPolicy;
 pub use ssl::{CaCertificate, ClientCertificate, PrivateKey, SslOption};