diff --git a/.gitignore b/.gitignore
index 7b1a5c4..a6bebdd 100644
--- a/.gitignore
+++ b/.gitignore
@@ -27,6 +27,12 @@ var/
 .installed.cfg
 *.egg
 
+# uv
+uv.lock
+.python-version
+
+.vscode/
+
 # PyInstaller
 #  Usually these files are written by a python script from a template
 #  before PyInstaller builds the exe, so as to inject date/other infos into it.
diff --git a/dev_requirements.txt b/dev_requirements.txt
deleted file mode 100644
index b00073a..0000000
--- a/dev_requirements.txt
+++ /dev/null
@@ -1,9 +0,0 @@
--r requirements.txt
-
-mock==3.0.5;python_version<"3.3"
-pytest==5.3.1;python_version>="3.5"
-pytest==4.6.6;python_version<"3.5"
-pytest-cov==2.8.1
-Sphinx==2.2.2;python_version>="3.5"
-Sphinx==1.8.5;python_version<"3.5"
-sphinx-rtd-theme==0.4.3
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000..2344bff
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,48 @@
+[project]
+name = "umodbus"
+version = "1.0.4"
+description = "Implementation of the Modbus protocol in pure Python"
+readme = "README.rst"
+license="MPL-2.0"
+requires-python = ">=3.5,<3.10"
+dependencies = [
+    "pyserial~=3.4",
+]
+classifiers=[
+    "Development Status :: 6 - Mature",
+    "Intended Audience :: Developers",
+    "Operating System :: OS Independent",
+    "Programming Language :: Python :: 3.5",
+    "Programming Language :: Python :: 3.6",
+    "Programming Language :: Python :: 3.7",
+    "Programming Language :: Python :: 3.8",
+    "Programming Language :: Python :: 3.9",
+    "Topic :: Software Development :: Embedded Systems",
+]
+authors= [{name="Auke Willem Oosterhoff", email="a.oosterhoff@climotion.com" }]
+[project.urls]
+homepage = "https://github.com/AdvancedClimateSystems/uModbus"
+source = "https://github.com/AdvancedClimateSystems/uModbus"
+issues = "https://github.com/AdvancedClimateSystems/uModbus/issues"
+documentation = "https://umodbus.readthedocs.io/en/latest/"
+
+[dependency-groups]
+dev = [
+    "pytest==5.3.1",
+    "pytest-cov==2.8.1",
+    "sphinx==2.2.2",
+    "sphinx-rtd-theme==0.4.3",
+]
+
+[build-system]
+requires = ["setuptools>=61.0"]
+build-backend = "setuptools.build_meta"
+
+[tool.setuptools]
+packages=[
+    "umodbus",
+    "umodbus.client",
+    "umodbus.client.serial",
+    "umodbus.server",
+    "umodbus.server.serial",
+]
diff --git a/requirements.txt b/requirements.txt
deleted file mode 100644
index 205196f..0000000
--- a/requirements.txt
+++ /dev/null
@@ -1 +0,0 @@
-pyserial==3.4
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index 79bc678..0000000
--- a/setup.cfg
+++ /dev/null
@@ -1,5 +0,0 @@
-[bdist_wheel]
-# This flag says that the code is written to work on both Python 2 and Python
-# 3. If at all possible, it is good practice to do this. If you cannot, you
-# will need to generate wheels for each Python version that you support.
-universal=1
diff --git a/setup.py b/setup.py
deleted file mode 100755
index 1c36cb5..0000000
--- a/setup.py
+++ /dev/null
@@ -1,44 +0,0 @@
-#!/usr/bin/env python
-"""
-uModbus is a pure Python implementation of the Modbus protocol with support
-for Python 2.7, 3.4, 3.5, 3.6, 3.7 and 3.8.
-
-"""
-import os
-from setuptools import setup
-
-cwd = os.path.dirname(os.path.abspath(__name__))
-
-long_description = open(os.path.join(cwd, 'README.rst'), 'r').read()
-
-setup(name='uModbus',
-      version='1.0.4',
-      author='Auke Willem Oosterhoff',
-      author_email='a.oosterhoff@climotion.com',
-      description='Implementation of the Modbus protocol in pure Python.',
-      url='https://github.com/AdvancedClimateSystems/umodbus/',
-      long_description=long_description,
-      license='MPL',
-      packages=[
-          'umodbus',
-          'umodbus.client',
-          'umodbus.client.serial',
-          'umodbus.server',
-          'umodbus.server.serial',
-      ],
-      install_requires=[
-          'pyserial~=3.4',
-      ],
-      classifiers=[
-          'Development Status :: 6 - Mature',
-          'Intended Audience :: Developers',
-          'License :: OSI Approved :: Mozilla Public License 2.0 (MPL 2.0)',
-          'Operating System :: OS Independent',
-          'Programming Language :: Python :: 2.7',
-          'Programming Language :: Python :: 3.4',
-          'Programming Language :: Python :: 3.5',
-          'Programming Language :: Python :: 3.6',
-          'Programming Language :: Python :: 3.7',
-          'Programming Language :: Python :: 3.8',
-          'Topic :: Software Development :: Embedded Systems',
-      ])