diff --git a/meteor/server/api/rest/v1/studios.ts b/meteor/server/api/rest/v1/studios.ts
index 75e3f2a10a..0b98c4b4a1 100644
--- a/meteor/server/api/rest/v1/studios.ts
+++ b/meteor/server/api/rest/v1/studios.ts
@@ -45,6 +45,11 @@ class StudiosServerAPI implements StudiosRestAPI {
 		_event: string,
 		apiStudio: APIStudio
 	): Promise<ClientAPI.ClientResponse<string>> {
+		const studioCount = await Studios.countDocuments()
+		if (studioCount > 0) {
+			return ClientAPI.responseError(UserError.create(UserErrorMessage.SystemSingleStudio, {}, 400))
+		}
+
 		const blueprintConfigValidation = await validateAPIBlueprintConfigForStudio(apiStudio)
 		checkValidation(`addStudio`, blueprintConfigValidation)
 
@@ -156,6 +161,14 @@ class StudiosServerAPI implements StudiosRestAPI {
 		event: string,
 		studioId: StudioId
 	): Promise<ClientAPI.ClientResponse<void>> {
+		const studioCount = await Studios.countDocuments()
+		if (studioCount === 1) {
+			throw new Meteor.Error(
+				400,
+				`The last studio in the system cannot be deleted (there must be at least one studio)`
+			)
+		}
+
 		const existingStudio = await Studios.findOneAsync(studioId)
 		if (existingStudio) {
 			const playlists = (await RundownPlaylists.findFetchAsync(
diff --git a/meteor/server/api/studio/api.ts b/meteor/server/api/studio/api.ts
index f5f75b7fe7..127db12777 100644
--- a/meteor/server/api/studio/api.ts
+++ b/meteor/server/api/studio/api.ts
@@ -38,6 +38,14 @@ async function insertStudio(context: MethodContext, newId?: StudioId): Promise<S
 	return insertStudioInner(null, newId)
 }
 export async function insertStudioInner(organizationId: OrganizationId | null, newId?: StudioId): Promise<StudioId> {
+	const studioCount = await Studios.countDocuments()
+	if (studioCount > 0) {
+		throw new Meteor.Error(
+			400,
+			`Only one studio is supported per installation (there are currently ${studioCount})`
+		)
+	}
+
 	return Studios.insertAsync(
 		literal<DBStudio>({
 			_id: newId || getRandomId(),
@@ -79,6 +87,14 @@ async function removeStudio(context: MethodContext, studioId: StudioId): Promise
 
 	assertConnectionHasOneOfPermissions(context.connection, ...PERMISSIONS_FOR_MANAGE_STUDIOS)
 
+	const studioCount = await Studios.countDocuments()
+	if (studioCount === 1) {
+		throw new Meteor.Error(
+			400,
+			`The last studio in the system cannot be deleted (there must be at least one studio)`
+		)
+	}
+
 	const studio = await Studios.findOneAsync(studioId)
 	if (!studio) throw new Meteor.Error(404, `Studio "${studioId}" not found`)
 
diff --git a/meteor/server/migration/X_X_X.ts b/meteor/server/migration/X_X_X.ts
index 9a1382d9d6..7c7cef98e2 100644
--- a/meteor/server/migration/X_X_X.ts
+++ b/meteor/server/migration/X_X_X.ts
@@ -1,6 +1,7 @@
 import { addMigrationSteps } from './databaseMigration'
 import { CURRENT_SYSTEM_VERSION } from './currentSystemVersion'
 import { MongoInternals } from 'meteor/mongo'
+import { Studios } from '../collections'
 
 /*
  * **************************************************************************************
@@ -44,4 +45,18 @@ export const addSteps = addMigrationSteps(CURRENT_SYSTEM_VERSION, [
 			}
 		},
 	},
+
+	{
+		id: 'Ensure a single studio',
+		canBeRunAutomatically: true,
+		validate: async () => {
+			const studioCount = await Studios.countDocuments()
+			if (studioCount === 0) return `No studios found`
+			if (studioCount > 1) return `There are ${studioCount} studios, but only one is supported`
+			return false
+		},
+		migrate: async () => {
+			// Do nothing, the user will have to resolve this manually
+		},
+	},
 ])
diff --git a/packages/corelib/src/error.ts b/packages/corelib/src/error.ts
index 65d3e4f57b..3cbf71c558 100644
--- a/packages/corelib/src/error.ts
+++ b/packages/corelib/src/error.ts
@@ -63,6 +63,7 @@ export enum UserErrorMessage {
 	IdempotencyKeyMissing = 47,
 	IdempotencyKeyAlreadyUsed = 48,
 	RateLimitExceeded = 49,
+	SystemSingleStudio = 50,
 }
 
 const UserErrorMessagesTranslations: { [key in UserErrorMessage]: string } = {
@@ -124,6 +125,7 @@ const UserErrorMessagesTranslations: { [key in UserErrorMessage]: string } = {
 	[UserErrorMessage.IdempotencyKeyMissing]: t(`Idempotency-Key is missing`),
 	[UserErrorMessage.IdempotencyKeyAlreadyUsed]: t(`Idempotency-Key is already used`),
 	[UserErrorMessage.RateLimitExceeded]: t(`Rate limit exceeded`),
+	[UserErrorMessage.SystemSingleStudio]: t(`System must have exactly one studio`),
 }
 
 export interface SerializedUserError {
diff --git a/packages/webui/src/client/ui/Settings/SettingsMenu.tsx b/packages/webui/src/client/ui/Settings/SettingsMenu.tsx
index 490070a0fa..788fd8005e 100644
--- a/packages/webui/src/client/ui/Settings/SettingsMenu.tsx
+++ b/packages/webui/src/client/ui/Settings/SettingsMenu.tsx
@@ -86,12 +86,16 @@ function SettingsMenuStudios() {
 		MeteorCall.studio.insertStudio().catch(catchError('studio.insertStudio'))
 	}, [])
 
+	// An installation should have only one studio https://github.com/Sofie-Automation/sofie-core/issues/1450
+	const canAddStudio = studios.length === 0
+	const canDeleteStudio = studios.length > 1
+
 	return (
 		<>
-			<SectionHeading title={t('Studios')} addClick={onAddStudio} />
+			<SectionHeading title={t('Studios')} addClick={canAddStudio ? onAddStudio : undefined} />
 
 			{studios.map((studio) => (
-				<SettingsMenuStudio key={unprotectString(studio._id)} studio={studio} />
+				<SettingsMenuStudio key={unprotectString(studio._id)} studio={studio} canDelete={canDeleteStudio} />
 			))}
 		</>
 	)
@@ -241,8 +245,9 @@ function SettingsCollapsibleGroup({
 
 interface SettingsMenuStudioProps {
 	studio: DBStudio
+	canDelete: boolean
 }
-function SettingsMenuStudio({ studio }: Readonly<SettingsMenuStudioProps>) {
+function SettingsMenuStudio({ studio, canDelete }: Readonly<SettingsMenuStudioProps>) {
 	const { t } = useTranslation()
 
 	const onDeleteStudio = React.useCallback(
@@ -291,9 +296,11 @@ function SettingsMenuStudio({ studio }: Readonly<SettingsMenuStudioProps>) {
 					<FontAwesomeIcon icon={faExclamationTriangle} />
 				</button>
 			) : null}
-			<button className="action-btn" onClick={onDeleteStudio}>
-				<FontAwesomeIcon icon={faTrash} />
-			</button>
+			{canDelete && (
+				<button className="action-btn" onClick={onDeleteStudio}>
+					<FontAwesomeIcon icon={faTrash} />
+				</button>
+			)}
 		</SettingsCollapsibleGroup>
 	)
 }