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  <title>Brent Y. Chick</title>
  <meta name="description" content="Brent Y. Chick — PhD student at the Salk Institute studying epigenetics, chromatin remodeling, and cell signaling.">
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      <div class="header-info">
        <h1>Brent Y. Chick</h1>
        <p class="subtitle">PhD Student &middot; Salk Institute &middot; La Jolla, CA</p>
        <p class="bio">
          Hi, I'm a senior PhD student at the Salk Institute in La Jolla, CA. My research couples
          bioengineering and sequencing approaches to explore how cells perceive and respond to their
          environment through the lens of chromatin dynamics. Fascinated by chromatin's ability to buffer
          noise and encode memory, I aim to understand and leverage these properties to develop new
          approaches to cell engineering and therapeutic design. As I approach the end of my PhD, I'm
          eager to bring this work into either academic or industry settings.
        </p>
        <div class="contact-links">
          <span><img src="images/email.png" alt="" class="icon" /> bchick [at] salk.edu</span>
          <a href="https://scholar.google.com/citations?user=QQkDZcAAAAAJ&hl=en"><img src="images/scholar.png" alt="" class="icon" /> Google Scholar</a>
          <a href="https://github.com/bchick"><img src="images/GitHub-Mark-120px-plus.png" alt="" class="icon" /> GitHub</a>
          <a href="https://www.linkedin.com/in/brent-chick-50898075/">LinkedIn</a>
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          <a href="assets/Brent_Chick_CV_OCT_2022.pdf" download><img src="images/document.png" alt="" class="icon" /> CV</a>
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        <h2>Research</h2>
        <p class="research-description">
          My work focuses on understanding how chromatin remodeling complexes — particularly BAF (SWI/SNF) —
          interpret cellular signals to reshape the epigenetic landscape and drive gene expression programs in
          immune cells. Using a combination of genomics, epigenomics, and bioengineering approaches, I study how
          transcription and chromatin remodeling are coordinated at gene regulatory elements and how these
          mechanisms control T cell differentiation and function.
        </p>
        <p class="research-description">
          My research has been published in <em>Nature</em>, <em>Nature Genetics</em>,
          <em>Immunity</em>, <em>Nature Methods</em>, <em>Cell Stem Cell</em>,
          <em>Cell Reports</em>, <em>The Journal of Immunology</em>, and <em>Blood</em>.
          Prior to joining Dr. Diana Hargreaves' lab at the Salk, I did my MA at UCSB with
          Dr. Max Wilson, performed research at UCLA under Dr. Gay Crooks and Dr. Chris Seet,
          and completed my BS at UCSD while working in the lab of Dr. Stephen Hedrick.
        </p>
      </section>

      <hr />

      <!-- Publications -->
      <section>
        <h2>Publications</h2>
        <ul class="publication-list">

          <li>
            <span class="pub-title"><a href="https://doi.org/10.1038/s41586-025-09989-7">Atlas-guided discovery of transcription factors for T cell programming</a></span><br />
            Chung HK, Chen S, Engel BJ, Bhatt RR, Li Y, Fang Q, Yang S, Zhang C, Coles GL, Bhatt DL, Pan X, Li Y, Li T, Rathore APS, Wen D, Adachi K, Song L, <b>Brent Chick</b>, Hargreaves DC, Zhang K, Bhatt DL, Wang W.
            <span class="pub-journal">Nature</span>, 2026.
          </li>

          <li>
            <span class="pub-title"><a href="https://doi.org/10.1101/2025.11.12.688147">The antiviral Interferon pathway drives astrocyte aging and motor decline</a></span><br />
            Labarta-Bajo L, Bhatt DL, Bhatt RR, Ye H, <b>Brent Y Chick</b>, Hargreaves DC, Allen NJ.
            <span class="pub-journal">bioRxiv</span>, 2025.
          </li>

          <li>
            <span class="pub-title"><a href="https://doi.org/10.1038/s41588-023-01628-z">RNA polymerase II promoter-proximal pausing promotes BAF chromatin binding and remodeling</a></span><br />
            <b>Brent Y Chick</b>, Hargreaves DC.
            <span class="pub-journal">Nature Genetics</span>, 2024.
          </li>

          <li>
            <span class="pub-title"><a href="https://doi.org/10.1016/j.immuni.2023.05.005">Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates</a></span><br />
            McDonald B<sup>&dagger;</sup>, <b>Brent Y Chick</b><sup>&dagger;</sup>, Ahmed MY, Burns E, Ma S, Casero D, Bhatt DL, Kaech SM.
            <span class="pub-journal">Immunity</span>, 2023.
            <span class="pub-note"><sup>&dagger;</sup>Co-first author</span>
          </li>

          <li>
            <span class="pub-title"><a href="https://doi.org/10.59249/AXGU7370">Early Chromatin Remodeling Events in Acutely Stimulated CD8+ T Cells</a></span><br />
            McDonald B<sup>&dagger;</sup>, <b>Brent Y Chick</b><sup>&dagger;</sup>, Hargreaves DC, Kaech SM.
            <span class="pub-journal">Yale Journal of Biology and Medicine</span>, 2023.
            <span class="pub-note"><sup>&dagger;</sup>Co-first author</span>
          </li>

          <li>
            <span class="pub-title"><a href="https://doi.org/10.1038/s41594-022-00858-9">Switching under selection: how CoREST controls endocrine therapy resistance in ER+ breast cancer</a></span><br />
            <b>Brent Y Chick</b>, Hargreaves DC.
            <span class="pub-journal">Nature Structural &amp; Molecular Biology</span>, 2022.
          </li>

          <li>
            <span class="pub-title"><a href="https://doi.org/10.1016/j.celrep.2020.108320">In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells</a></span><br />
            Montel-Hagen A, Sun V, Casero D, Tsai S, Zampieri A, Jackson N, Li S, Lopez S, Zhu Y, <b>Brent Chick</b>, He C, de Barros SC, Seet CS, Crooks GM.
            <span class="pub-journal">Cell Reports</span>, 2020.
          </li>

          <li>
            <span class="pub-title"><a href="https://www.jimmunol.org/content/205/9/2483.abstract">Pleiotropic Roles of VEGF in the Microenvironment of the Developing Thymus</a></span><br />
            de Barros SC, Suterwala BT, He C, Ge S, <b>Brent Chick</b>, Blumberg GK, Kim K, Klein S, Zhu Y, Wang X, Casero D, Crooks GM.
            <span class="pub-journal">The Journal of Immunology</span>, 2020.
          </li>

          <li>
            <span class="pub-title"><a href="https://doi.org/10.1016/j.stem.2018.12.011">Organoid-induced differentiation of conventional T cells from human pluripotent stem cells</a></span><br />
            Montel-Hagen A, Seet CS, Li S, <b>Brent Chick</b>, Zhu Y, Chang P, Tsai S, Sun V, Lopez S, Chen HC, He C, Chin CJ, Casero D, Crooks GM.
            <span class="pub-journal">Cell Stem Cell</span>, 2019.
          </li>

          <li>
            <span class="pub-title"><a href="https://www.exphem.org/article/S0301-472X(18)30440-5/fulltext">Notch Signaling Regulates the Differentiation of CLEC9A+ Dendritic Cells (cDC1) From Human and Mouse Hematopoietic Stem/Progenitor Cells</a></span><br />
            Seet CS, Li S, <b>Brent Chick</b>, Casero D, Kim J, Gschweng E, Chen HC, Zhu Y, Lopez S, Miao R, Montel-Hagen A, Kohn D, Sehl M, Crooks GM.
            <span class="pub-journal">Experimental Hematology</span>, 2018.
          </li>

          <li>
            <span class="pub-title"><a href="https://www.nature.com/articles/nmeth.4237">Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids</a></span><br />
            Seet CS, He C, Bethune MT, Li S, <b>Brent Chick</b>, Gschweng EH, Zhu Y, Kim K, Kohn DB, Baltimore D, Crooks GM, Montel-Hagen A.
            <span class="pub-journal">Nature Methods</span>, 2017.
          </li>

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