The understanding of the impact of inherited and somatic genome variants on phenotypes and diseases requires a thorough understanding of such variants amongst populations in general and carriers of the phenotypes and diseases in particular. Such information can only be provided through the inclusion of data from a multitude of genome resources in variant evaluation efforts, including such from outside (international) jurisdictions. However, opening such resources carries the inherent risk of breaching privacy, particularly through re-identification of individuals or their relatives and potentially through the exposure of individual genome-related personal information including phenotypic and "performance" prediction and relative disease risk.
0 commit comments