diff --git a/packages/ketcher-standalone/src/infrastructure/services/struct/standaloneStructService.ts b/packages/ketcher-standalone/src/infrastructure/services/struct/standaloneStructService.ts
index cbc5d306c8..8fd98b34e4 100644
--- a/packages/ketcher-standalone/src/infrastructure/services/struct/standaloneStructService.ts
+++ b/packages/ketcher-standalone/src/infrastructure/services/struct/standaloneStructService.ts
@@ -222,7 +222,9 @@ class IndigoService implements StructService {
     this.worker = indigoWorker;
     this.worker.onmessage = (e: MessageEvent<OutputMessage<string>>) => {
       if (e.data.type === Command.Info) {
-        const callbackMethod = process.env.SEPARATE_INDIGO_RENDER
+        const isSeparateRender =
+          typeof process !== 'undefined' && process.env?.SEPARATE_INDIGO_RENDER;
+        const callbackMethod = isSeparateRender
           ? this.callIndigoNoRenderLoadedCallback
           : this.callIndigoLoadedCallback;