diff --git a/rust/Cargo.lock b/rust/Cargo.lock
index 601c0c2..5d54c0e 100644
--- a/rust/Cargo.lock
+++ b/rust/Cargo.lock
@@ -83,7 +83,7 @@ dependencies = [
  "cfg-if",
  "crossbeam-utils",
  "lazy_static",
- "memoffset",
+ "memoffset 0.6.4",
  "scopeguard",
 ]
 
@@ -241,6 +241,15 @@ dependencies = [
  "autocfg",
 ]
 
+[[package]]
+name = "memoffset"
+version = "0.8.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d61c719bcfbcf5d62b3a09efa6088de8c54bc0bfcd3ea7ae39fcc186108b8de1"
+dependencies = [
+ "autocfg",
+]
+
 [[package]]
 name = "num"
 version = "0.4.0"
@@ -407,13 +416,14 @@ dependencies = [
 
 [[package]]
 name = "pyo3"
-version = "0.16.6"
+version = "0.18.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "0220c44442c9b239dd4357aa856ac468a4f5e1f0df19ddb89b2522952eb4c6ca"
+checksum = "06a3d8e8a46ab2738109347433cb7b96dffda2e4a218b03ef27090238886b147"
 dependencies = [
  "cfg-if",
  "indoc",
  "libc",
+ "memoffset 0.8.0",
  "parking_lot",
  "pyo3-build-config",
  "pyo3-ffi",
@@ -423,9 +433,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-build-config"
-version = "0.16.6"
+version = "0.18.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "9c819d397859445928609d0ec5afc2da5204e0d0f73d6bf9e153b04e83c9cdc2"
+checksum = "75439f995d07ddfad42b192dfcf3bc66a7ecfd8b4a1f5f6f046aa5c2c5d7677d"
 dependencies = [
  "once_cell",
  "target-lexicon",
@@ -433,9 +443,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-ffi"
-version = "0.16.6"
+version = "0.18.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ca882703ab55f54702d7bfe1189b41b0af10272389f04cae38fe4cd56c65f75f"
+checksum = "839526a5c07a17ff44823679b68add4a58004de00512a95b6c1c98a6dcac0ee5"
 dependencies = [
  "libc",
  "pyo3-build-config",
@@ -443,9 +453,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros"
-version = "0.16.6"
+version = "0.18.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "568749402955ad7be7bad9a09b8593851cd36e549ac90bfd44079cea500f3f21"
+checksum = "bd44cf207476c6a9760c4653559be4f206efafb924d3e4cbf2721475fc0d6cc5"
 dependencies = [
  "proc-macro2",
  "pyo3-macros-backend",
@@ -455,9 +465,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.16.6"
+version = "0.18.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "611f64e82d98f447787e82b8e7b0ebc681e1eb78fc1252668b2c605ffb4e1eb8"
+checksum = "dc1f43d8e30460f36350d18631ccf85ded64c059829208fe680904c65bcd0a4c"
 dependencies = [
  "proc-macro2",
  "quote",
diff --git a/rust/Cargo.toml b/rust/Cargo.toml
index 1215c42..63948b5 100644
--- a/rust/Cargo.toml
+++ b/rust/Cargo.toml
@@ -14,6 +14,6 @@ paste = "1.0.11"
 itertools = "0.10.5"
 md-5 = "0.10.5"
 num = "0.4.0"
-pyo3 = { version = "0.16.6", features = ["extension-module"] }
+pyo3 = { version = "0.18.1", features = ["extension-module"] }
 rayon = "1.6.1"
 regex = "1.7.0"