When I run the model in this vignette locally, I get the median agomelatine concentration as about 1.65 ng/mL and are never NA. While the simulations on GitLab are lower and are sometimes NA. @mattfidler, can you identify any reason why concentrations in the calmt measure would be lower and sometimes NA here?
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d_sim_pop <- nlmixr2(Xie_2019_agomelatine, data = d_sim_prep, est = "rxSolve", control = list(nStud = 1000)) |