diff --git a/.github/workflows/base-ci.yaml b/.github/workflows/base-ci.yaml
index 4e1425e..522d818 100644
--- a/.github/workflows/base-ci.yaml
+++ b/.github/workflows/base-ci.yaml
@@ -31,8 +31,11 @@ jobs:
         fail-fast: false
         matrix:
           os: [macOS-13, macOS-latest, ubuntu-latest]
-          python-version: ["3.11", "3.12"]
+          python-version: ["3.11", "3.12", "3.13"]
           include-openeye: [false, true]
+          exclude:
+            - include-openeye: true
+              python-version: "3.13"  # OpenEye not supported on Python 3.13 yet
 
     steps:
     - uses: actions/checkout@v5
diff --git a/.github/workflows/gh-ci.yaml b/.github/workflows/gh-ci.yaml
index e9621cf..3d33146 100644
--- a/.github/workflows/gh-ci.yaml
+++ b/.github/workflows/gh-ci.yaml
@@ -31,7 +31,7 @@ jobs:
         fail-fast: false
         matrix:
           os: [macOS-13, macOS-latest, ubuntu-latest]
-          python-version: ["3.11", "3.12"]
+          python-version: ["3.11", "3.12", "3.13"]
           pydantic-version: ["1", "2"]
           include-rdkit: [false, true]
           include-openeye: [false, true]
@@ -39,6 +39,14 @@ jobs:
           exclude:
             - include-rdkit: false
               include-openeye: false
+            - include-openeye: true
+              python-version: "3.13"  # OpenEye not supported on Python 3.13 yet
+            - include-dgl: true
+              python-version: "3.13"  # DGL not supported on Python 3.13 yet
+            - include-dgl: false
+              include-openeye: false
+              os: macOS-13  # AmberTools not on macOS-13 for Python 3.13
+              python-version: "3.13"
 
 
     steps:
diff --git a/devtools/conda-envs/test_env_dgl_true.yaml b/devtools/conda-envs/test_env_dgl_true.yaml
index 3b9fe8c..eb6471a 100644
--- a/devtools/conda-envs/test_env_dgl_true.yaml
+++ b/devtools/conda-envs/test_env_dgl_true.yaml
@@ -23,7 +23,7 @@ dependencies:
   - pyarrow
 
   # gcn
-  - dgl =2.1
+  - dgl =2.3
   - pytorch >=2.0
   - pytorch-lightning