diff --git a/pandas/core/indexing.py b/pandas/core/indexing.py
index f1f453cf433cf..4a8792f72a604 100644
--- a/pandas/core/indexing.py
+++ b/pandas/core/indexing.py
@@ -1989,7 +1989,8 @@ def _setitem_with_indexer_split_path(self, indexer, value, name: str):
                     return self._setitem_with_indexer((pi, info_axis[0]), value[0])
 
                 raise ValueError(
-                    "Must have equal len keys and value when setting with an iterable"
+                    f"Length mismatch when setting Dataframe with an iterable. "
+                    f"Keys: {pi}, Values: {value}"
                 )
 
             elif lplane_indexer == 0 and len(value) == len(self.obj.index):
@@ -2017,7 +2018,8 @@ def _setitem_with_indexer_split_path(self, indexer, value, name: str):
 
             else:
                 raise ValueError(
-                    "Must have equal len keys and value when setting with an iterable"
+                    f"Length mismatch when setting Dataframe with an iterable. "
+                    f"Keys: {pi}, Values: {value}"
                 )
 
         else:
diff --git a/pandas/tests/frame/indexing/test_setitem.py b/pandas/tests/frame/indexing/test_setitem.py
index 20dd7b0c4d3e7..e8ca540f39696 100644
--- a/pandas/tests/frame/indexing/test_setitem.py
+++ b/pandas/tests/frame/indexing/test_setitem.py
@@ -1098,7 +1098,7 @@ def test_setitem_loc_empty_indexer_raises_with_non_empty_value(self, box):
             indexer = box([], dtype="object")
         else:
             indexer = box([])
-        msg = "Must have equal len keys and value when setting with an iterable"
+        msg = "Length mismatch when setting Dataframe with an iterable"
         with pytest.raises(ValueError, match=msg):
             df.loc[indexer, ["b"]] = [1]
 
diff --git a/pandas/tests/indexing/multiindex/test_setitem.py b/pandas/tests/indexing/multiindex/test_setitem.py
index d732cb4d7fbbc..c5d6298ed4527 100644
--- a/pandas/tests/indexing/multiindex/test_setitem.py
+++ b/pandas/tests/indexing/multiindex/test_setitem.py
@@ -225,7 +225,7 @@ def test_multiindex_assignment_single_dtype(self):
         tm.assert_series_equal(df.loc[4, "c"], exp)
 
         # invalid assignments
-        msg = "Must have equal len keys and value when setting with an iterable"
+        msg = "Length mismatch when setting Dataframe with an iterable"
         with pytest.raises(ValueError, match=msg):
             df.loc[4, "c"] = [0, 1, 2, 3]
 
diff --git a/pandas/tests/indexing/multiindex/test_slice.py b/pandas/tests/indexing/multiindex/test_slice.py
index 7f298e9bdd375..468b31920a189 100644
--- a/pandas/tests/indexing/multiindex/test_slice.py
+++ b/pandas/tests/indexing/multiindex/test_slice.py
@@ -660,7 +660,7 @@ def test_per_axis_per_level_setitem(self):
                 [[100], [100, 100]], dtype="int64"
             )
 
-        msg = "Must have equal len keys and value when setting with an iterable"
+        msg = "Length mismatch when setting Dataframe with an iterable"
         with pytest.raises(ValueError, match=msg):
             df.loc[(slice(None), 1), (slice(None), ["foo"])] = np.array(
                 [100, 100, 100, 100], dtype="int64"
diff --git a/pandas/tests/indexing/test_indexing.py b/pandas/tests/indexing/test_indexing.py
index 113eb6c2b2c31..6d1f42adf7c6b 100644
--- a/pandas/tests/indexing/test_indexing.py
+++ b/pandas/tests/indexing/test_indexing.py
@@ -46,7 +46,7 @@ def test_setitem_ndarray_1d(self):
         df["bar"] = np.zeros(10, dtype=complex)
 
         # invalid
-        msg = "Must have equal len keys and value when setting with an iterable"
+        msg = "Length mismatch when setting Dataframe with an iterable"
         with pytest.raises(ValueError, match=msg):
             df.loc[df.index[2:5], "bar"] = np.array([2.33j, 1.23 + 0.1j, 2.2, 1.0])
 
@@ -67,7 +67,7 @@ def test_setitem_ndarray_1d_2(self):
         df["foo"] = np.zeros(10, dtype=np.float64)
         df["bar"] = np.zeros(10, dtype=complex)
 
-        msg = "Must have equal len keys and value when setting with an iterable"
+        msg = "Length mismatch when setting Dataframe with an iterable"
         with pytest.raises(ValueError, match=msg):
             df[2:5] = np.arange(1, 4) * 1j
 
@@ -1036,7 +1036,7 @@ def test_scalar_setitem_with_nested_value(value):
     df = DataFrame({"A": [1, 2, 3]})
     msg = "|".join(
         [
-            "Must have equal len keys and value",
+            "Length mismatch when setting Dataframe with an iterable",
             "setting an array element with a sequence",
         ]
     )
@@ -1046,7 +1046,9 @@ def test_scalar_setitem_with_nested_value(value):
     # TODO For object dtype this happens as well, but should we rather preserve
     # the nested data and set as such?
     df = DataFrame({"A": [1, 2, 3], "B": np.array([1, "a", "b"], dtype=object)})
-    with pytest.raises(ValueError, match="Must have equal len keys and value"):
+    with pytest.raises(
+        ValueError, match="Length mismatch when setting Dataframe with an iterable"
+    ):
         df.loc[0, "B"] = value
     # if isinstance(value, np.ndarray):
     #     assert (df.loc[0, "B"] == value).all()