diff --git a/docs/release.rst b/docs/release.rst
index ac4f851d..5e80861b 100644
--- a/docs/release.rst
+++ b/docs/release.rst
@@ -27,6 +27,8 @@ Improvements
   By :user:`John Kirkham <jakirkham>`, :issue:`723`
 * All codecs are now pickleable.
   By :user:`Tom Nicholas <TomNicholas>`, :issue:`744`
+* The Zstandard codec can now decode bytes containing multiple frames
+  By :user:`Mark Kittisopikul <mkitti>`, :issue:`757`
 
 Fixes
 ~~~~~
diff --git a/numcodecs/tests/test_pyzstd.py b/numcodecs/tests/test_pyzstd.py
index b9dd6db2..7ee6084b 100644
--- a/numcodecs/tests/test_pyzstd.py
+++ b/numcodecs/tests/test_pyzstd.py
@@ -25,7 +25,6 @@ def test_pyzstd_simple(input):
     assert pyzstd.decompress(z.encode(input)) == input
 
 
-@pytest.mark.xfail
 @pytest.mark.parametrize("input", test_data)
 def test_pyzstd_simple_multiple_frames_decode(input):
     """
diff --git a/numcodecs/tests/test_zstd.py b/numcodecs/tests/test_zstd.py
index 04b474df..a3a926eb 100644
--- a/numcodecs/tests/test_zstd.py
+++ b/numcodecs/tests/test_zstd.py
@@ -156,3 +156,34 @@ def zstd_cli_available() -> bool:
     return not subprocess.run(
         ["zstd", "-V"], stdout=subprocess.DEVNULL, stderr=subprocess.DEVNULL
     ).returncode
+
+
+def test_multi_frame():
+    codec = Zstd()
+
+    hello_world = codec.encode(b"Hello world!")
+    assert codec.decode(hello_world) == b"Hello world!"
+    assert codec.decode(hello_world * 2) == b"Hello world!Hello world!"
+
+    hola = codec.encode(b"Hola ")
+    mundo = codec.encode(b"Mundo!")
+    assert codec.decode(hola) == b"Hola "
+    assert codec.decode(mundo) == b"Mundo!"
+    assert codec.decode(hola + mundo) == b"Hola Mundo!"
+
+    bytes_val = b'(\xb5/\xfd\x00Xa\x00\x00Hello World!'
+    dec = codec.decode(bytes_val)
+    dec_expected = b'Hello World!'
+    assert dec == dec_expected
+    cli = zstd_cli_available()
+    if cli:
+        assert bytes_val == generate_zstd_streaming_bytes(dec_expected)
+        assert dec_expected == generate_zstd_streaming_bytes(bytes_val, decompress=True)
+
+    # Concatenate frames of known sizes and unknown sizes
+    # unknown size frame at the end
+    assert codec.decode(hola + mundo + bytes_val) == b"Hola Mundo!Hello World!"
+    # unknown size frame at the beginning
+    assert codec.decode(bytes_val + hola + mundo) == b"Hello World!Hola Mundo!"
+    # unknown size frame in the middle
+    assert codec.decode(hola + bytes_val + mundo) == b"Hola Hello World!Mundo!"
diff --git a/numcodecs/zstd.pyx b/numcodecs/zstd.pyx
index f93da633..b3cc19f3 100644
--- a/numcodecs/zstd.pyx
+++ b/numcodecs/zstd.pyx
@@ -68,10 +68,12 @@ cdef extern from "zstd.h":
     size_t ZSTD_freeDStream(ZSTD_DStream* zds) nogil
     size_t ZSTD_initDStream(ZSTD_DStream* zds) nogil
 
-    cdef long ZSTD_CONTENTSIZE_UNKNOWN
-    cdef long ZSTD_CONTENTSIZE_ERROR
+    cdef unsigned long long ZSTD_CONTENTSIZE_UNKNOWN
+    cdef unsigned long long ZSTD_CONTENTSIZE_ERROR
+
     unsigned long long ZSTD_getFrameContentSize(const void* src,
                                                 size_t srcSize) nogil
+    size_t ZSTD_findFrameCompressedSize(const void* src, size_t srcSize) nogil
 
     int ZSTD_minCLevel() nogil
     int ZSTD_maxCLevel() nogil
@@ -216,7 +218,11 @@ def decompress(source, dest=None):
     try:
 
         # determine uncompressed size
-        dest_size = ZSTD_getFrameContentSize(source_ptr, source_size)
+        try:
+            dest_size = findTotalContentSize(source_ptr, source_size)
+        except RuntimeError:
+            raise RuntimeError('Zstd decompression error: invalid input data')
+
         if dest_size == 0 or dest_size == ZSTD_CONTENTSIZE_ERROR:
             raise RuntimeError('Zstd decompression error: invalid input data')
 
@@ -353,6 +359,46 @@ cdef stream_decompress(const Py_buffer* source_pb):
 
     return dest
 
+cdef unsigned long long findTotalContentSize(const char* source_ptr, size_t source_size):
+    """Find the total uncompressed content size of all frames in the source buffer
+
+    Parameters
+    ----------
+    source_ptr : Pointer to the beginning of the buffer
+    source_size : Size of the buffer containing the frame sizes to sum
+
+    Returns
+    -------
+    total_content_size: Sum of the content size of all frames within the source buffer
+        If any of the frame sizes is unknown, return ZSTD_CONTENTSIZE_UNKNOWN.
+        If any of the frames causes ZSTD_getFrameContentSize to error, return ZSTD_CONTENTSIZE_ERROR.
+    """
+    cdef:
+        unsigned long long frame_content_size = 0
+        unsigned long long total_content_size = 0
+        size_t frame_compressed_size = 0
+        size_t offset = 0
+
+    while offset < source_size:
+        frame_compressed_size = ZSTD_findFrameCompressedSize(source_ptr + offset, source_size - offset);
+
+        if ZSTD_isError(frame_compressed_size):
+            error = ZSTD_getErrorName(frame_compressed_size)
+            raise RuntimeError('Could not set determine zstd frame size: %s' % error)
+
+        frame_content_size = ZSTD_getFrameContentSize(source_ptr + offset, frame_compressed_size);
+
+        if frame_content_size == ZSTD_CONTENTSIZE_ERROR:
+            return ZSTD_CONTENTSIZE_ERROR
+
+        if frame_content_size == ZSTD_CONTENTSIZE_UNKNOWN:
+            return ZSTD_CONTENTSIZE_UNKNOWN
+
+        total_content_size += frame_content_size
+        offset += frame_compressed_size
+
+    return total_content_size
+
 class Zstd(Codec):
     """Codec providing compression using Zstandard.