diff --git a/drivers/misc/stm32n6_axisram/Kconfig b/drivers/misc/stm32n6_axisram/Kconfig
index b6c2493ac6e1d..7d583aec7ce44 100644
--- a/drivers/misc/stm32n6_axisram/Kconfig
+++ b/drivers/misc/stm32n6_axisram/Kconfig
@@ -4,4 +4,7 @@
 config STM32N6_AXISRAM
 	bool
 	select USE_STM32_HAL_RAMCFG
-	default y if DT_HAS_ST_STM32N6_RAMCFG_ENABLED
+	default y if $(dt_nodelabel_enabled,axisram3) || \
+		     $(dt_nodelabel_enabled,axisram4) || \
+		     $(dt_nodelabel_enabled,axisram5) || \
+		     $(dt_nodelabel_enabled,axisram6)
diff --git a/dts/arm/st/n6/stm32n6.dtsi b/dts/arm/st/n6/stm32n6.dtsi
index 5fdd55295b2d0..4112350a58151 100644
--- a/dts/arm/st/n6/stm32n6.dtsi
+++ b/dts/arm/st/n6/stm32n6.dtsi
@@ -852,6 +852,14 @@
 			resets = <&rctl STM32_RESET(APB5, 1)>;
 			status = "disabled";
 		};
+
+		npu: npu@580c0000 {
+			compatible = "st,stm32-npu";
+			reg = <0x580c0000 0x1000>;
+			clocks = <&rcc STM32_CLOCK(AHB5, 31)>;
+			resets = <&rctl STM32_RESET(AHB5, 31)>;
+			status = "disabled";
+		};
 	};
 };
 
diff --git a/dts/arm/st/n6/stm32n657X0.dtsi b/dts/arm/st/n6/stm32n657X0.dtsi
index e692de0af9756..ab4cb6f326024 100644
--- a/dts/arm/st/n6/stm32n657X0.dtsi
+++ b/dts/arm/st/n6/stm32n657X0.dtsi
@@ -22,7 +22,7 @@
 		ramcfg@42023100 {
 			axisram3: memory@34200000 {
 				reg = <0x34200000 DT_SIZE_K(448)>;
-				status = "okay";
+				status = "disabled";
 			};
 		};
 
diff --git a/dts/bindings/misc/st,stm32-npu.yaml b/dts/bindings/misc/st,stm32-npu.yaml
new file mode 100644
index 0000000000000..84cb2e047d15b
--- /dev/null
+++ b/dts/bindings/misc/st,stm32-npu.yaml
@@ -0,0 +1,18 @@
+# Copyright (c) 2025 STMicroelectronics
+# SPDX-License-Identifier: Apache-2.0
+
+description: STM32 Neural-ART accelerator
+
+compatible: "st,stm32-npu"
+
+include: [reset-device.yaml, base.yaml]
+
+properties:
+  reg:
+    required: true
+
+  clocks:
+    required: true
+
+  resets:
+    required: true
diff --git a/soc/st/stm32/stm32n6x/CMakeLists.txt b/soc/st/stm32/stm32n6x/CMakeLists.txt
index c2a8c56b3c0d1..966ce4a109f4d 100644
--- a/soc/st/stm32/stm32n6x/CMakeLists.txt
+++ b/soc/st/stm32/stm32n6x/CMakeLists.txt
@@ -5,6 +5,10 @@ zephyr_sources(
   soc.c
   )
 
+zephyr_sources_ifdef(CONFIG_STM32N6_NPU
+  npu/npu_stm32n6.c
+  )
+
 zephyr_include_directories(.)
 
 set(SOC_LINKER_SCRIPT ${ZEPHYR_BASE}/include/zephyr/arch/arm/cortex_m/scripts/linker.ld CACHE INTERNAL "")
diff --git a/soc/st/stm32/stm32n6x/Kconfig b/soc/st/stm32/stm32n6x/Kconfig
index 548dea00772fb..c1ac71d118cec 100644
--- a/soc/st/stm32/stm32n6x/Kconfig
+++ b/soc/st/stm32/stm32n6x/Kconfig
@@ -23,3 +23,8 @@ config SOC_SERIES_STM32N6X
 
 config STM32N6_BOOT_SERIAL
 	bool "Serial boot target (USB)"
+
+config STM32N6_NPU
+	bool "Neural-ART accelerator (NPU)"
+	select USE_STM32_HAL_RIF
+	default y if DT_HAS_ST_STM32_NPU_ENABLED
diff --git a/soc/st/stm32/stm32n6x/npu/npu_stm32n6.c b/soc/st/stm32/stm32n6x/npu/npu_stm32n6.c
new file mode 100644
index 0000000000000..77c307f649687
--- /dev/null
+++ b/soc/st/stm32/stm32n6x/npu/npu_stm32n6.c
@@ -0,0 +1,73 @@
+/*
+ * Copyright (c) 2025 STMicroelectronics
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+#define DT_DRV_COMPAT st_stm32_npu
+
+#include <errno.h>
+
+#include <zephyr/device.h>
+#include <zephyr/drivers/reset.h>
+#include <zephyr/init.h>
+#include <soc.h>
+
+#include <zephyr/drivers/clock_control/stm32_clock_control.h>
+
+/* Read-only driver configuration */
+struct npu_stm32_cfg {
+	/* Clock configuration. */
+	struct stm32_pclken pclken;
+	/* Reset configuration */
+	const struct reset_dt_spec reset;
+};
+
+static void npu_risaf_config(void)
+{
+	RIMC_MasterConfig_t RIMC_master = {0};
+
+	RIMC_master.MasterCID = RIF_CID_1;
+	RIMC_master.SecPriv = RIF_ATTRIBUTE_SEC | RIF_ATTRIBUTE_PRIV;
+	HAL_RIF_RIMC_ConfigMasterAttributes(RIF_MASTER_INDEX_NPU, &RIMC_master);
+	HAL_RIF_RISC_SetSlaveSecureAttributes(RIF_RISC_PERIPH_INDEX_NPU,
+					      RIF_ATTRIBUTE_SEC | RIF_ATTRIBUTE_PRIV);
+}
+
+static int npu_stm32_init(const struct device *dev)
+{
+	const struct device *const clk = DEVICE_DT_GET(STM32_CLOCK_CONTROL_NODE);
+	const struct npu_stm32_cfg *cfg = dev->config;
+
+	if (!device_is_ready(clk)) {
+		return -ENODEV;
+	}
+
+	if (clock_control_on(clk, (clock_control_subsys_t) &cfg->pclken) != 0) {
+		return -EIO;
+	}
+
+	if (!device_is_ready(cfg->reset.dev)) {
+		return -ENODEV;
+	}
+
+	/* Reset timer to default state using RCC */
+	(void)reset_line_toggle_dt(&cfg->reset);
+
+	npu_risaf_config();
+
+	return 0;
+}
+
+
+static const struct npu_stm32_cfg npu_stm32_cfg = {
+	.pclken = {
+		.enr = DT_CLOCKS_CELL(DT_NODELABEL(npu), bits),
+		.bus = DT_CLOCKS_CELL(DT_NODELABEL(npu), bus),
+	},
+	.reset = RESET_DT_SPEC_GET(DT_NODELABEL(npu)),
+};
+
+DEVICE_DT_DEFINE(DT_NODELABEL(npu), npu_stm32_init, NULL,
+		 NULL, &npu_stm32_cfg, POST_KERNEL,
+		 CONFIG_APPLICATION_INIT_PRIORITY, NULL);