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  • University Children's Hospital of Zurich
  • Zurich, Switzerland

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CharbelMachaalani/README.md

Hi, Charbel here 👋

Pronounced “Shar-bel” (more precisely: /ˈʃɑːr.bɛl/)
[Common pronunciation in Lebanese and other Middle Eastern contexts]


Computational Biologist (in the making) | Researcher | Pediatric Neuro-Oncology | Translational Medicine | Spatial Biology Enthusiast

📍 Zürich, Switzerland
📧 [email protected]
🌐 LinkedIn


My Research Journey 🗺️

I started out as a classic wet-lab scientist — the pipette kind, not the laptop kind.

My early toolkit included:

  • Western blots (yes, I’ve spilled milk)
  • RT-qPCR
  • Lentiviral transduction
  • Cell culture marathons
  • Creating Drosophila transgenic lines 🪰🪰🪰
  • Microscope gymnastics for tiny dissections
  • Taking fancy SEM -scanning electron microscopy- images of fly eyes (they are pretty)

I loved the hands-on work, the experiments, the troubleshooting-that-turns-into-career-therapy… all of it.


Fast-forward ⏭️⏭️⏭️ Early 2023

I jumped into a PhD exploring why some pediatric low-grade gliomas don’t respond to treatment.

This pulled me deep into the world of:

  • Molecular profiling
  • Bulk sequencing
  • Spatial proteomics
  • Single-nuclei multiome (RNA + ATAC)

This all happened despite me never taking a formal bioinformatics / CS / stats course.
Translation: I spent months googling what everyone else pretended to “just know.”
But I fell in love with computational biology — and now I can’t imagine doing research without it.


What I'm Currently Up To 🔬💻

  • Integrating multiome and spatial datasets to understand tumor evolution
  • Learning to survive (and occasionally enjoy) R, and nextflow
  • Trying to make sense of weird cell clusters 👀
  • Slowly becoming the “tech” person in the lab even though I never meant to

Projects and Contributions

🟢 ORCID

💻 Personal repos and publication --> coming soon ... ⏳


Always Happy to Connect 🤝

If you’re into brain tumors, spatial biology, multiomics, or just want to talk sci-comm, tech, or careers — feel free to reach out!

Popular repositories Loading

  1. scCustomize scCustomize Public

    Forked from samuel-marsh/scCustomize

    R package with collection of functions created and/or curated to aid in the visualization and analysis of single-cell data using R.

    R 1

  2. gdal gdal Public

    Forked from OSGeo/gdal

    GDAL is an open source MIT licensed translator library for raster and vector geospatial data formats.

    C++

  3. TACCO TACCO Public

    Forked from simonwm/tacco

    TACCO: Transfer of Annotations to Cells and their COmbinations

    Python

  4. SpatialScore SpatialScore Public

    Forked from nolanlab/SpatialScore

    R script for calculating the SpatialScore as described in our manuscript: "Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma".

    R

  5. NicheDE NicheDE Public

    Forked from kaishumason/NicheDE

    NicheDE is a method that detects context dependent changes in gene expression in spatial transcriptomic data.

    R

  6. CharbelMachaalani CharbelMachaalani Public