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DNA methylation of the human ventricles

Overview

This repository contain code for the following preprint: doi: https://doi.org/10.1101/2025.08.26.25334499. Following scripts were used for the analyses:

  • QC_and_normalisation: Quality control, normalisation, and batch correction.
  • exploratory_analysis: Exploratory analysis including principal component analysis, heatmap, density plots and sample-sample correlations.
  • differential_methylation_combat: Modelling DNA methylation differences among left and right ventricle and septum.
  • characterisation_of_DMRs: Characterisation of differentially methylated regions including over representation analysis
  • visualisation_DMRs: Visualisation of location of differentially methylated regions in comparison to previously identified differentially accessible regions and transcribed regulatory elements

Code

The s_names, scroll_table, and s_table helper functions are available from https://github.com/SteffanChristiansen/noecodedup/

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